AERO- AND CRYOGELS BASED ON BIOPOLYMERS - VERSATILE MATERIALS FOR MEDICAL APPLICATIONS
Funding program: 3. European and international cooperation
Subprogram: 3.1 Bilateral/multilateral
Project short title/Acronym: BIOGELS
Project code: PN-III-P3-3.1-PM-RO
Project no.: 84 BM/6.04.2017
Project leader - Romanian team: Dr. Diana Elena Ciolacu
Project leader - French team: Dr. Tatiana Budtova
Program manager (executing funding organisation): Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI)
Contractor: "Petru Poni" Institute of Macromolecular Chemistry
Duration of the project: 6 April 2017 – 31 December 2018
Total project costs: 25.483 lei
2017 - 18.525 lei
2018 - 6.958lei
The present project aims to obtain xero-, aero- and cryogels with designed properties as versatile materials for biomedical applications and to develop the existing collaboration, that is mutually beneficial, in the field of polysaccharides porous matrices.
The originality of the project is the fact that starting from the same precursor (cellulose or pectin) three-dimensional (3D) polymeric materials will be obtained, which will be further dried by different methods (xero-, aero- and cryo-) and subsequently tested for two biomedical applications: drugs controlled release systems and scaffolds for tissue engineering.
In this context, an understanding of the influence of polysaccharide state (solution or gel) and drying mode (xero-, aero- or cryo-) on the morphology and final porosity of the materials, will be pursued. The purpose of the project is to obtain versatile porous polymeric materials, providing "recipes" that lead to a certain morphology and, as a consequence, to a particular biomedical application. Finally, matrices prepared from natural polysaccharides and from mixtures of natural/microbial polysaccharides will be compared in terms of efficiency/performance for the chosen scope. The evaluation of polymer matrices in order to identify the requirements to be met for biomedical applications will be achieved through drug release studies and biocompatibility studies (viability and cell proliferation).
Stage I – AERO- AND CRYOGELS BASED ON BIOPOLYMERS
O.I.1. Preparation of cellulose-based cryogels
O.I.2. Physico-chemical characterization of cellulose and pectin aero- and cryogels by ATR-FTIR, XRD, DSC
Stage II - DRUG CONTROLLED RELEASE AND BIOCOMPATIBILITY STUDIES OF POLYMERIC MATRICES
O.II.1. Biocompatibility studies of hydrogels
O.II.2. Controlled release study of active principles in cellulose-based porous matrices
O.II.3. Testing the selected porous matrices as supports for cell cultures